Prof Research published a new report on the HPLC Columns market. It presents the largest 20 manufacturers in the HPLC Columns Market. The report is a professional and in-depth study on the current state of the global HPLC Columns market. The report provides key statistics on the market of HPLC Columns. It is a valuable source of guidance and direction for companies and individuals interested in the HPLC Columns industry.

The global High-Performance Liquid Chromatography (HPLC) Columns market was valued at USD 1,647.1 million in 2024 and is projected to reach USD 2,137.3 million by 2030, growing at a CAGR of 4.44% during the forecast period. The increasing need for precision analytical testing, advancements in pharmaceutical and biotechnological research, and expanding applications in food safety, environmental analysis, and clinical diagnostics are key drivers of market growth.

HPLC columns are essential components of analytical systems used for separation, identification, and quantification of compounds. The growing demand for high-resolution, high-throughput, and reproducible chromatographic methods has led to continuous innovation in column design and stationary phase chemistry. In particular, the rise of bioanalytical applications, peptide mapping, metabolomics, and pharmaceutical quality control has significantly boosted column utilization across laboratories worldwide.

Agilent Technologies, headquartered in the United States, is the global leader in the HPLC columns market with a 14.36% share. Agilent’s column portfolio covers a wide range of stationary phases — including ZORBAX, Poroshell, and Polaris series — designed for analytical, preparative, and UHPLC applications. The company’s strength lies in broad compatibility with instruments, superior column reproducibility, and strong customer support across pharma, life sciences, and environmental sectors. Agilent continues to expand in biochromatography and peptide purification, leveraging its expertise in materials science and chromatography software integration.

Shimadzu, based in Japan, ranks second with 13.7% market share. It offers a comprehensive portfolio of HPLC columns optimized for analytical precision, including Shim-pack VP, GIST, and Mastro series. Shimadzu’s competitive advantage lies in instrument-column system integration, ensuring high performance, reliability, and reproducibility. The company heavily invests in LC–MS coupling technologies and green analytical chemistry, with focus areas in pharmaceutical validation and clinical diagnostics.

Thermo Fisher Scientific, a U.S.-based multinational, holds 12.75% of the market. It offers industry-leading brands like Accucore, Hypersil GOLD, and Acclaim columns, known for their high efficiency and consistent separation performance. The company’s extensive distribution network, combined with innovations in nano- and micro-bore columns, gives it strong penetration in proteomics, metabolomics, and biopharma analysis. Thermo Fisher continues to strengthen its market leadership through integrated workflows and customized chromatography solutions.

Waters, headquartered in the U.S., accounts for 10.43% of global HPLC column sales. The company pioneered the BEH, XBridge, and CORTECS columns that revolutionized modern UHPLC and bioseparation technologies. Waters maintains a strong foothold in pharmaceutical R&D, clinical diagnostics, and academic research, supported by its Empower software ecosystem and continuous product innovation. It remains a benchmark brand for quality, durability, and analytical precision.